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Liver Complications from Prescription Drug Xarelto

Posted on in Prescription Drugs

By Shawn Kasserman

xarelto liver injury, Chicago personal injury lawyers

While the majority of injury claims associated with Xarelto involve serious, uncontrollable, and irreversible bleeding, other side effects have begun to surface. One such adverse event, as highlighted in a 2014 publication in JAMA Internal Medicine and an investigation conducted by Health Canada, is the potential for severe and systemic drug-induced liver damage. Dangerous, in and of itself, this risk is not made known to doctors or patients, giving it all the potential and markings needed for becoming a silent, widespread killer.

Reports of Postmarketing Liver Injury Risk

After two patients had been found to suffer from liver injury with hyperbilirubinemia (adult jaundice), Swiss researchers investigated other possible liver injury cases. Between the years 2008 and 2013, they uncovered another 14 liver injury cases with potential links to the new but increasingly popular blood thinner. The additional cases could not be irrefutably linked, but researchers claimed that the two patients who had prompted the investigation showed rapid biochemical and clinical recovery after discontinuing Xarelto.

In light of the study, and with 61 reports made through the agency’s Canada Vigilance Program, Health Canada launched a probe investigation into the liver injury risks of Xarelto in August of 2015. They turned up another 431 international cases of liver damage in Xarelto users, but most were taking other medications as well; only 23 of the cases involved patients taking only Xarelto. In the end, Health Canada felt they were unable to establish a clear link between Xarelto and liver injury, but they state they will continue to monitor it for its safety.

Clinical Trials and the Link to Liver Injury

When considering a publication found in the United States National Library of Medicine, it becomes apparent that the manufacturers of Xarelto, Janssen Pharmaceuticals, and Bayer, may have been aware of potential liver injury risks prior to marketing the drug. Several instances of elevated liver enzymes (ALT) with jaundice were allegedly documented in their pre-licensure clinical trials, but few details were provided regarding those cases, other than how the cessation of Xarelto completely resolved the issue. Yet, outside of being contraindicated in patients with renal impairment, no warning regarding potential liver injury exists on the drug’s list of complications or risks.

Xarelto Injuries or Complications? Seek Assistance from a Skilled Attorney

If you or a loved one has an injury or complication that may be related to taking Xarelto, you may be able to file a claim against the manufacturers. Committed to protecting the rights of victims, the experienced Chicago Xarelto personal injury attorneys at Tomasik Kotin Kasserman can help. Call 312-605-8800 and schedule your free initial consultation to learn more.

Sources:

http://www.hc-sc.gc.ca/dhp-mps/medeff/reviews-examens/xarelto-eng.php

http://archinte.jamanetwork.com/article.aspx?articleID=1898869

http://www.empr.com/medical-news/rivaroxaban-and-liver-injury-case-studies-add-to-safety-questions/article/368881/

http://livertox.nih.gov/Rivaroxaban.htm

http://teamxarelto.com/shared/product/xarelto/prescribing-information.pdf

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